Pain relief with cbd: how to manage it and best products

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Cannabis has been proven over the years to be one of the best natural herbs to aid in healing abilities. In addition to helping relieve symptoms of arthritis, skin inflammation and diabetes, cannabis can also minimize or treat chronic pain.

The use of cannabidiol is widespread and, like many herbal remedies, has no significant side effects. Cannabis also works with the endocannabinoid system to help treat chronic pain associated with various conditions such as arthritis and multiple sclerosis. Some people even try to replace their pharmaceutical products with CBD. There are many opportunities to incorporate cannabis into your life. Some people prefer to smoke the plant through vaporizers, while others prefer pills or tinctures. Read on to learn more about CBD and pain management.

CBD Oil for Cancer Pain Management

Cancer-related pain affects your quality of life, your routine activities, eating habits, your ability to sleep well at night, and even the way you interact with others. Pain management is an important part of overall cancer treatment, and most people confirm that cannabis and CBD oil help manage the side effects that occur with cancer treatment. Studies are also investigating how cannabis can help with cancer.

Research on Cancer and CBD Oil

Cannabis, which has been used for centuries as an herbal medicine to treat various ailments, is now recognized as a medicine used to address various health conditions. With the use of cannabis products for therapeutic purposes growing exponentially, researchers from around the world have dedicated themselves to discovering how cannabis can help treat cancer. In general, studies include both natural and man-made cannabis products such as hemp oil, cannabis butter and cannabinoids. Cannabinoids, the active ingredients found in hemp, are complex substances extracted from the cannabis plant. They help regulate the biological functions of our body. Delta-9-tetrahydrocannabinol, also called THC, is useful for dealing with the side effects of chemotherapy. Cannabidiol, also called CBD, is another cannabinoid that has the potential to manage painful conditions such as cancer.

Researchers have discovered that our body also creates cannabinoid-like chemicals found in our endocannabinoid system. Cannabinoid receptors, called CB1 and CB2, are found in different parts of our body and perform different functions. The CB1 receptor is found in cells of the nervous system, especially in brain cells and the body’s nerves, while CB2 receptors are found in cells of the immune system. According to researchers, both endocannabinoid and cannabinoid receptors are involved in bodily functions such as heart functioning, control of brain activity, pain, immune system functions and reproduction. This molecular multitasking has led to the involvement of receptors in a wide range of diseases, from neurodegenerative disorders to cancer.

Recent research on cannabinoids

Research on whether cannabinoids can be used to treat cancer is ongoing. Scientists often grow cancer cells in the laboratory or use animal models to study the effects of cannabinoids on cancer cells. Recently, scientists have found that cannabinoids have the following effects in the laboratory –

  • Stopping cell division
  • Inducing cell death through the process of apoptosis
  • Preventing cancer cells from spreading by preventing their effects on neighboring tissues
  • Accelerating the process of autophagy leading to cell death.

These effects are due to CB1 and CB2 receptors. Recent experiments with high doses of THC in mice have shown to reduce the risk of cancer cell proliferation. Therefore, the use of high doses of THC can help destroy cancer cells. Therefore, research has found positive results following the use of cannabinoids derived from both the cannabis plant and synthetic compounds.

Complementary cancer treatment with CBD oil

Often cancer treatment worsens the overall health of the patient, as it leads to quite serious side effects. In such cases, the use of CBD oil can act as a complementary treatment to make the patient feel better. Many people undergoing cancer treatment claim that cannabis helps to cope with side effects such as pain, loss of appetite, nausea and vomiting, and cachexia. There can be almost unbearable pain associated with cancer treatment due to nerve damage, pressure on internal organs and inflammation. Cannabis has anti-inflammatory properties and thus improves pain. THC reduces pain caused by nerve damage by acting on CB1 receptors. In addition to reducing pain, cannabis also helps to reduce nausea and increase appetite.

CBD oil can therefore help manage cancer pain as a complementary treatment, as it copes with most side effects. It helps manage chronic pain, which in turn allows patients to better withstand the cancer treatment process.

CBD and neuropathic pain treatment

Anyone who has experienced neuropathy knows that it is a uniquely distressing experience. The sensations of electrical tingling, burning, stinging and pins and needles usually occur in the extremities, but can occur anywhere in the body. Nerve pain is unique in that it is caused by damage to the nerves themselves (slipped discs, pinched nerves, chronic conditions such as multiple sclerosis or damage from an injury) rather than the surrounding tissues. Neuropathic pain is therefore the result of a malfunctioning pain perception system in your body.

Cannabidiol or CBD has been shown to provide neuroprotective, anti-inflammatory, analgesic, antioxidant and antispasmodic effects that can be successfully applied to neuropathic pain treatment regimens. Derived from hemp and known for its efficacy without the risk of addiction or dependence, CBD can be used orally, inhaled or applied topically for the relief of neuropathic pain.

While these supportive ingredients open many doors for more effective pain relief, they also increase the risk of side effects, especially in people with sensitive or allergy-prone skin. Topical CBD products have their place in the treatment of neuropathic pain, but the wrong supporting ingredients for your skin type can reduce (or even completely eliminate) their benefits.

Here, we will demonstrate the physiology of neuropathy before discussing the role of topical CBD in relief. We will then talk about the best carriers and supporting ingredients for neuropathic pain relief; including how they work, what they are best for, and the risks associated with them. Finally, we will finish with a brief note about resistant components.

What causes neuropathic pain?

Your nervous system is made up of several different key players: neurons, myelin and glial cells. Neurons are like your body’s electrical wires that carry signals to and from your brain. They are long, branching cells that use charged molecules to carry signals along the length of the cell before transferring them to the next one.

Neuropathy occurs when any of these nerve cells are damaged. This damage can be caused by many different things. Although injuries such as a herniated disc or a pinched nerve can cause physical strain and damage to neurons, they are not the only possible causes. Chronic conditions such as multiple sclerosis, diabetes (even pre-diabetes) and cardiovascular disease can cause nerve cell damage by altering the chemical environment in the body or by causing immune cells to mistakenly attack nerve tissue.

So why is nerve damage so big and why does it cause such strange and severe pain? Think of nerves and their myelin as an electric wire coated with rubber. If this rubber coating is damaged, electricity no longer flows cleanly along the wire, but can cause short circuits, sparks or even stop altogether. Your neurons work in a similar way, and the damaged neuron is more likely to send erroneous pain signals when there is nothing wrong; the more severe the nerve damage, the more intense the neuropathy.

How can CBD help manage neuropathic pain?

So far this may sound a bit grim, but stay with us. It is true that the science of nerve damage recovery is still a long way off, but that does not mean that relief is out of reach. While research is still in its infancy, existing studies show that CBD has neuroprotective and antispasmodic properties and can help calm frayed neurons and relieve neuropathic pain.

The exact mechanisms of this effect are still under investigation, but what we do know is that CBD has a positive regulatory effect on many systems of the body, including the nervous system. This means that CBD can help reduce the frequency and intensity of neuropathic pain signals by calming overstimulated neurons and reducing the inflammation and pain often associated with them. It may also reduce the tingling, burning, pricking and stinging sensations common in neuropathy, as well as the cramping and involuntary contractions often associated with the condition.

Current research suggests that topical CBD application may be more effective for neuropathy than conventional treatments, including opioid painkillers. However, due to the greater number of supporting ingredients compared to oral CBD, topical agents carry a relatively higher risk of adverse or allergic reactions. In addition, their effects can vary significantly from product to product depending on the carrier and supporting ingredients they contain.

Topical CBD Carrier Oils for Nerve Pain

Carrier oils and other key ingredients have a significant impact on the overall effect and especially the sensory effects of the final product. Since sensation is so important for effectively managing and soothing neuropathic pain, we think a little more information about carrier ingredients can help our readers more easily navigate the amazing variety of topical CBD products available and find the best formula for their needs.

Because CBD is a non-polar molecule, it is insoluble in water, which is a polar molecule. This makes it difficult for our bodies to absorb and metabolize it – after all, more than 70% of us are water, and water is the solvent for most of our biological processes. Despite not dissolving easily in water, CBD binds well to lipids such as oils and fats and vegetable oils. When bound to these compounds, CBD is much more easily absorbed by the body, which significantly increases its effectiveness. This applies to both topical and oral CBD products. Due to their buttery composition and emollient properties, these ingredients are often the best at promoting soothing and warming sensations.

However, lipids are not the only type of molecule that can help make your CBD dose more bioavailable; other molecules with relatively weak polar charge can also be effective. These compounds can include things like aloe vera gel, various types of alcohol or glycerol. Unlike the heavy, oily feel of lipid products, these “polar light” molecules tend to evaporate more easily, making them ideal for maintaining cooling, tingling or numbing effects.

If your nerve pain feels like burning, stinging or pins and needles, a cooling product can help reduce pain by regulating the firing of damaged nerves. Whenever possible, we recommend choosing products made with aloe vera, glycerol or cetyl alcohol. This is because other alcohols such as isopropyl, stearyl or ethyl can damage the bonds between skin cells over time, increasing dryness and causing discomfort. In contrast, cetyl alcohol is a fatty alcohol derived from coconut that can be less harmful (but those allergic to coconut should avoid it).

If you want something with more warming, relaxing properties to help relieve cramps, we recommend choosing products formulated with oils, candles or vegetable oils. Plant-derived oils such as olive, avocado, safflower, argan, jojoba, grapeseed, almond and coconut can be used in combination with vegetable oils such as shea, cocoa and mango for creamy formulas, while carnauba or beeswax can give a firmer, ointment-like consistency. We have found that more emollient formulas keep warming ingredients like ginger, cinnamon and capsaicin active longer and prolong symptom relief.

If you prefer not to use products that manipulate your senses and perceptions, that’s okay! There are many useful topical CBD products that do not cause any heat sensations. We recommend choosing a carrier according to your skin type and avoiding ingredients that tend to cause changes in the sense of touch. These are usually things like menthol, capsaicin, cinnamon and ginger, but sometimes it can also contain milder extracts like lavender or arnica, so listen to your body on this one.

If you want to try topical CBD for nerve pain but have very sensitive skin that avoids most of the mainstream ingredients, don’t give up hope yet. Instead of reaching for a topical formula with a long list of ingredients, try using an unflavored CBD tincture made from just CBD and a suitable carrier oil. You can safely apply it to your skin without worrying about hidden allergies while benefiting from the pain-relieving, anti-inflammatory and antispasmodic properties of topical CBD. If you decide to try a topical formula, we recommend a balm or ointment that usually contains fewer common allergens than creams, lotions or roll-on formulas.

Neuropathic pain is quite difficult to treat, but CBD can provide relief where other treatments have failed. Topical application of CBD can be particularly helpful in peripheral neuropathy, soothing the numbness, burning and stabbing pain often associated with nerve damage. While CBD has strong therapeutic potential for neuropathic pain, the right ingredients can make a significant difference in your health experience. We recommend paying attention to what the label on your topical CBD products says – when in doubt, contact the manufacturer with any questions or concerns.

Topical CBD Supporting Ingredients for Nerve Pain

  • Capsaicin Capsaicin, the chemical that gives chili peppers their characteristic bitterness (and chili peppers their infamous burn), certainly has inflammatory potential. However, in small doses, the fiery compound can actually act as an anti-inflammatory, stimulating circulation and reducing pain and swelling. It also creates a warming sensation when applied to the skin (again, well diluted), which may be useful for relieving some types of nerve pain. Researchers think this analgesic effect may be partly due to the fact that this sensation helps to desensitize the skin and thus the sensation of pain. Capsaicin is used in very small doses in CBD topical pain relief products and is generally well tolerated. However, those who are allergic to pepper should be careful to avoid it.
  • Clove – While not as effective for deep-seated neuropathy in fascia, clove oil works very well to soothe the sensation of neuropathic pain in the skin and superficial tissues. Clove is a small but powerful spice with surprisingly strong analgesic properties. Clove oil has been shown to be as effective as benzocaine in relieving pain when applied topically. There is also some evidence that clove may have a positive regulatory effect on the nerves, helping to regulate their function and potentially reducing the intensity and sensation of pain. Clove has an autumnal, spicy aroma and is generally well tolerated, but should be avoided by people with clove allergies.
  • Eucalyptus – Eucalyptus is widely used for its analgesic and anti-inflammatory properties (and its ability to clear a stuffy nose). The extract of eucalyptus, an aromatic tree native to Australia, may play a role in relieving neuropathic pain. Although the mechanism has not yet been fully elucidated, two factors appear to be at work. Eucalyptus exhibits analgesic properties when applied topically and may help reduce the sensitivity of damaged nerves by regulating their firing. Secondly, the aroma of eucalyptus may influence the processing of pain signals by the central nervous system by reducing pain perception. Asthma sufferers should be warned that eucalyptus may trigger attacks in some people (although it may be beneficial for others).
  • Feverfew – The name of this herb comes from its traditional use in treating pain and inflammation. The leaves and flowers of feverfew, also known as bachelor’s mace, produce compounds that reduce muscle spasms and the burning, tingling, prickling sensation associated with neuropathic pain. It has been shown to have analgesic and antispasmodic properties when applied to the skin, but how these effects occur is not fully understood. New research suggests that this may be due to the terpenes, flavonoids and other bioactive compounds in poplar extract. If this is the case, these terpenes and other phytochemicals may help support the dose of CBD in a topical pain reliever.
  • Ginger – A favorite spicy remedy in the kitchen, ginger’s use as an anti-inflammatory, pain reliever and antiemetic is well documented in history. The root extract of the plant can help relieve neuropathic pain and soothe inflamed nerves when applied topically. It can also cause a slight warming, tingling sensation on the skin, which can help numb neuropathic pain while desensitizing damaged nerves and regulating their firing. These benefits are also evident when ginger is consumed (although a separate supplement should be used), indicating that it may also be beneficial in the diet of people struggling with neuropathy. People with ginger allergies or certain sensory integration issues should exercise caution before using topical CBD products made with ginger.
  • Lavender – A perennial favorite in aromatherapy and home fragrances, lavender has long had anxiolytic, anti-inflammatory, analgesic and hypnotic properties. When applied to the skin, it is antifungal and antibacterial, as well as pain relieving, making it a potentially good option for [injury recovery]. Research has shown that lavender can help reduce migraine pain and relieve the severity and intensity of neuropathic pain. The calming effect of aromatherapy lavender may also help reduce the perception of pain in the central nervous system. Those allergic to lavender should be cautious as it is a popular ingredient in many topical CBD products for pain relief.
  • Peppermint – Peppermint (and other members of the mint genus, such as spearmint) contains menthol, a popular ingredient in topical pain products because of the cooling sensation it produces when applied to the skin. Some people may find that menthol is what helps them manage their neuropathic pain. This may be because of menthol’s effect on receptors in the skin, sensitizing them to the sensation of cold and thus potentially relieving burning or stinging pain. The other two main components of peppermint extract, limonene and carvacrol, have also been found to help relieve pain and inflammation when used externally. To get the full therapeutic benefit, look for products that contain peppermint extract, not just menthol, and keep any substance containing peppermint or menthol away from mucous membranes. Be careful with peppermint (and other types of mint) if you are allergic or have particularly sensitive skin.
  • Rosemary – A popular culinary favorite in culinary traditions around the world, rosemary is a shrubby herb rich in terpenes, flavonoids and other phytochemicals that may be effective against neuropathy. The herb has been used in the past against pain, fever and seizures, and current research suggests it may have antispasmodic properties. One study shows that rosemary is effective in relaxing smooth muscles (muscles over which you have no conscious control; they contract involuntarily and can cause debilitating pain due to their proximity to organs and bones). This property may make rosemary a soothing antispasmodic additive to topical CBD products for neuropathic pain.
  • Turmeric – Turmeric, a brightly colored root popular in Southeast Asian cuisine, is extremely high in a compound called curcumin. Curcumin is used to fight pain, fever and inflammation, and research suggests it may also be useful for neuropathic pain. Although more studies are needed, curcumin relieves pain by acting on receptors that can help block neuropathic pain signals. When applied topically, curcumin may reduce the frequency and intensity of neuropathic pain by regulating the activity of damaged neurons. It is generally well tolerated, but should not be used by people allergic to turmeric.

CBD and fibromyalgia

Fibromyalgia is a potentially debilitating condition that causes widespread muscle tenderness, pain and fatigue. Associated with arthritis, fibromyalgia can make even simple activities difficult or impossible. As a chronic condition, fibromyalgia can be treated but not cured. Like many other chronic conditions, fibromyalgia pain is often difficult to treat and can involve harsh medications.

How can CBD help fibromyalgia?

Fibromyalgia is a condition that involves multiple manageable but chronic symptoms, including pain, fatigue, mood swings and memory loss. The disorder is thought to change the way the brain processes pain signals, thereby intensifying all bodily pain. Fibromyalgia affects more women than men and is most common in adults aged 40-75.

Although researchers are not entirely sure what causes fibromyalgia, some studies suggest that genetics may be involved. The increased pain sensitivity associated with fibromyalgia is thought to be caused by low levels of certain brain neurotransmitters, including serotonin and norepinephrine.

Current treatments for fibromyalgia include pharmaceuticals and self-care, such as taking action to improve overall health. Treatments vary depending on symptoms, but range from painkillers, antidepressants (to help treat pain and fatigue) and anti-seizure medications (which can help reduce some pain and other symptoms of fibromyalgia).

The Science of CBD for Fibromyalgia

The human body is fully equipped with an endocannabinoid system consisting of various receptors that help the brain communicate with the rest of the body. A 2016 study published in the journal Cannabis and Cannabinoid Research presents research supporting the theory that a deficiency of endocannabinoids, neurotransmitters that bind to endocannabinoid receptors and facilitate cellular communication, may be the cause of treatment-resistant chronic pain syndromes. These include migraine, irritable bowel syndrome and fibromyalgia. CBD for fibromyalgia can help treat this deficiency, thus leading to a reduction in the intensity of symptoms.

The endocannabinoid system sends pain signals between the brain and the body. CBD has been found to alter these neural pathways and thus the pain felt in the body. This, together with research showing the anti-inflammatory effects of CBD, may explain why CBD is an effective treatment for many fibromyalgia sufferers.

It should be noted that CBD only reduces fibromyalgia symptoms in some patients. Like all medicines, CBD is not a magic panacea and may be ineffective for some people. Before CBD is officially established as a treatment for fibromyalgia, more research is needed to understand the advances in the science of CBD for fibromyalgia, as well as why it works for some and not for others. However, some current research hopes to illuminate the path to discovering CBD’s full therapeutic potential for fibromyalgia.

Current Research: Study Results

A 2008 study reviewed the scientific literature through the National Library of Medicine database and other sources to investigate how clinical endocannabinoid deficiency could explain why migraine, fibromyalgia and irritable bowel syndrome are alleviated by cannabis. “Cannabinoids have similarly demonstrated the ability to block spinal, peripheral, and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS, and related disorders.”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/18404144

A 2019 study examined the effects of inhaled pharmaceutical cannabis in a randomized placebo-controlled trial. Four different cannabis strains containing different levels of CBD and THC were tested in 20 patients with chronic pain and fibromyalgia. “[M]ore participants taking Bediol [13.4 mg THC, 17.8 mg CBD] showed a 30% reduction in pain scores compared to placebo (90% vs. 55% of patients).”

Learn more: https://journals.lww.com/pain/Fulltext/2019/04000/An_experimental_randomized_study_on_the_analgesic.11.aspx

Recommended CBD regimen for fibromyalgia

Fibromyalgia can cause constant pain that makes even the most enjoyable activities difficult. Like many chronic conditions, fibromyalgia pain can be difficult to manage. Can CBD help fibromyalgia and if so, how? Here we will take a look at the scientific evidence for CBD in fibromyalgia. We will look at the causes and symptoms of fibromyalgia and associated pain before discussing how CBD can help relieve these symptoms. We will also provide some dosage guidelines to help you incorporate CBD into your fibro healing routine.

Fibromyalgia is a chronic condition that requires daily treatment. When considering CBD as a treatment modality, keep in mind that the benefits of CBD for fibromyalgia have not yet been proven. However, many people find that regular CBD application, either systemically or topically, helps to improve their discomfort.

For body pain, we recommend a topical product such as CBD lotion that can be applied directly to the affected area. This will provide localized, long-lasting relief when and where you need it. Apply liberally and be sure to massage into the skin.

For daily relaxation and general mood stabilization, we also recommend taking CBD tincture every morning. Start with a low dose (one full drop) and increase as needed. If you are new to tinctures, try a flavored variety and mix it into your coffee or tea.

Although CBD for fibromyalgia can be effective for many people, it is important to note that it is not a cure. Many people report that CBD for fibromyalgia tends to work best when accompanied by traditional pharmaceutical medicines and lifestyle changes. Treatment will be different for each patient, but studies have shown that CBD can offer a solution to many of the ailments associated with the condition. The best first step may be to talk to your doctor about CBD.

It is also worth noting that while the Food and Drug Administration (FDA) recognizes the potential value CBD may have, to date it has not yet approved it as a regulated treatment option. While the Agriculture Improvement Act (also known as the Farm Bill) in 2018 regulates industrial hemp, it does not change the legal status of CBD. Overall, more research and clinical studies will be needed to fully understand how this natural substance can help treat this chronic disease.

Results of studies on CBD and pain management

Specific studies on the use and pharmacokinetics of cannabinoids for pain management date back more than a decade. To date, numerous research efforts have been directed towards explaining how cannabidiol may work to help relieve pain. This wide range of research has explored the use of CBD for pain in a variety of ways, alone, in combination with THC, and in the form of cannabinoid-based pharmaceuticals.

Overall, research suggests that cannabidiol may be useful for managing pain from a variety of conditions, including neuropathic pain, such as pain associated with multiple sclerosis. Studies have also shown that CBD may be a viable treatment option for pain caused by inflammation, such as pain due to arthritis or muscle injury. Research even suggests that cannabinoid-based therapies may be suitable for the relief of intractable pain due to cancer.

Research on the use of CBD for pain is still in its infancy, but researchers are showing clear interest in CBD’s anti-inflammatory and neuroprotective properties, as well as its use to address pain associated with various neurological and physical conditions. These studies suggest that different dosing methods, ranging from oral doses to transdermal administration, may be suitable for managing pain associated with one or more of these conditions.

1. Cannabinoids for pain management

A 2008 article reviewed several studies on cannabinoid analgesia and the function of the endocannabinoid system in relation to pain mechanisms, as well as numerous clinical trials on the use of cannabinoids for pain management. The article concludes: ” Cannabinoid analgesics are generally well tolerated in clinical trials with acceptable adverse event profiles. Their addition to pharmacologic armamentarium for pain management is promising.

For more information: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

2. A meta-analysis on pain associated with multiple sclerosis

A 2007 study examined the effect of cannabinoids in the treatment of debilitating pain experienced by 50-70% of patients with multiple sclerosis (MS). The double-blind placebo-controlled study concluded that “cannabinoids, including buccal cannabidiol (CBD)/THC spray, are effective in the treatment of neuropathic pain in MS”.

For more information: https://www.ncbi.nlm.nih.gov/pubmed/17257464

3. Two-Year Neuropathic Pain Trial

Another study in 2007 evaluated the long-term tolerability and effects of the THC/CBD drug known as Sativex. The study concluded “THC/CBD was effective without evidence of tolerability in selected CNP and MS patients who completed approximately 2 years of treatment”.

For more information: https://www.ncbi.nlm.nih.gov/pubmed/18035205

4. Cannabinoids for neuropathic pain

In a 2014 study “The endocannabinoid system has been elucidated over the past few years and has shown a significant interaction with pain homeostasis. Exogenous (plant-based) cannabinoids have been shown to be effective in a number of experimental models of neuropathic pain and there is growing evidence for their therapeutic use in human neuropathic pain conditions.”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/25160710

5. Neuropathic Orofacial Pain and Its Treatment

In another study from 2014 “Analgesia is one of the main therapeutic targets of the cannabinoid system, and many studies have demonstrated the efficacy of cannabinoid compounds in the treatment of neuropathic pain.”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/25150831

6. Cannabidiol on the efficacy of nervous system chemotherapy

A 2014 study investigated the therapeutic potential of CBD in the treatment of chemotherapy-induced neuropathic pain (CIPN). The researchers concluded that “adjunctive CBD treatment during chemotherapy for PAC may be safe and effective in preventing or alleviating chemotherapy-induced neuropathic pain.”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/24117398

7. Antihyperalgesic Effects of Cannabis in the Rat

A 2008 study found that “a controlled cannabis extract containing multiple cannabinoids and other non-cannabinoid fractions (terpenes and flavonoids) in a defined ratio provided antinociceptive efficacy superior to a single cannabinoid administered alone.” Using a full-spectrum CBD oil is therefore more effective in treating pain than taking CBD isolate alone – you want to get the beneficial terpenes and flavonoids found in the plant.

For more information: Non-psychoactive cannabinoids that modulate antinociception

A 2011 study evaluated the effects of two non-psychoactive cannabinoids – cannabidiol (CBD) and cannabichromene (CBC) – on pain management. The study concluded that: “CBD and CBC stimulate downstream antinociception pathways and induce analgesia by interacting with various target proteins involved in nociceptive control. These compounds may represent useful therapeutic agents with multiple mechanisms of action.”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/20942863

9. Cannabinoids suppress inflammation via α3 glycine receptors

A 2012 study reported that “systemic and intrathecal administration of cannabidiol (CBD), an important non-psychoactive component of marijuana, and its modified derivatives significantly suppressed chronic inflammatory and neuropathic pain without inducing overt analgesic tolerance.. these cannabinoids may represent a new class of therapeutic agents for the treatment of chronic pain and other diseases…”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/22585736

10. Efficacy of THC:CBD extract in cancer-related pain

A 2010 study examined the efficacy, safety and tolerability of THC:CBD extract in patients with persistent cancer-related pain. ” This study shows that THC:CBD extract is effective for pain relief in patients with advanced cancer pain that is not fully relieved by strong opioids .”

For more information: https://www.ncbi.nlm.nih.gov/pubmed/19896326

Risks of CBD for Patients with Chronic Pain

Although CBD has been declared generally safe by many studies and even by the World Health Organization, it is important to note that CBD can interact with some medications. Just as grapefruit interacts with some medications, CBD can affect the absorption of drugs that are metabolized by the cytochrome P450 enzyme group. This is because CBD also relies on this group of liver enzymes for absorption, so there is a significant potential for interaction when drugs and CBD are taken at the same time.

The interaction can include most prescription drugs taken for pain, such as opioids, which often use cytochrome P450 pathways for absorption. These interactions are not necessarily dangerous, but can lead to a weakening of the drug’s effect, which can be dangerous if the drug is intended to treat severe symptoms or a chronic condition.

The effect of CBD on these liver enzymes is temporary. Often putting some distance between the pain and the dose of CBD for the medication can solve this problem, but it is always best to talk to your doctor about CBD before use, especially if you are already taking prescription medication or have a chronic condition.

Synergistic Effects of THC and CBD for Pain

Although THC, the ingredient responsible for the “high” feeling in cannabis, gets most of the attention and press (after all, psychoactive substances are often eye-catching as chemical compounds), scientists and the general public are becoming more aware of another cannabis ingredient with medicinal properties, CBD: CBD. CBD has been gaining popularity in recent years, but its role in cannabis use is still not entirely clear. Its therapeutic benefits are clear, with potential applications in everything from sleep disorders to chronic pain, post-traumatic stress to inflammatory bowel disease.

In addition to its own properties, there is some evidence to suggest that CBD can work together with THC and other cannabinoids and produce synergistic effects that the individual components do not produce. This theory is known as the Entourage Effect and is widely accepted in cannabis user circles. In particular, there is some evidence to support a synergistic relationship between THC and CBD, which means that the two compounds can work together to produce effects not found in the pure form of the two compounds.

Composition of cannabis

Cannabis is a complex plant made up of more than 400 chemical components. Of these, more than 113 are classified as cannabinoids, meaning they bind to cannabinoid receptors in the body. You also naturally produce cannabinoids (these are called endocannabinoids and contribute to the feeling of calm and well-being often experienced after exercise, especially after endurance activities), so you have receptors for them in your central nervous system.

CBD is also a cannabinoid, but it does not have the psychoactive effects of THC, which means that no amount of CBD will get you high. However, like THC, it also provides medical benefits such as relieving chronic pain, anxiety and nausea, as well as potential benefits for ailments ranging from cardiovascular disease to stroke and diabetes. CBD in particular appears to be a promising treatment for drug-resistant epilepsy. Although much more research is needed, preliminary results are positive, and because it carries no potential for abuse, CBD can be ordered online and shipped to all 50 US states.

We know that CBD and THC can be used alone (in the form of isolated concentrates) to achieve different effects, but what about using them together as we do when we consume whole flowers and whole plant concentrates? If you are a medical user, there are benefits to consuming THC and CBD together and there is evidence to suggest a synergistic relationship between the effects of THC and CBD in treating various conditions.

Synergy between THC and CBD

Some studies have shown a synergistic relationship between THC and CBD, especially in medical applications. A 2008 study found that there is evidence to support a synergistic relationship between cannabinoids and terpenes, particularly in the treatment of the following conditions: chronic inflammation, pain, anxiety and depression; epilepsy; cancer; fungal and bacterial infections; and addiction. The exact mechanism of this synergy is not yet known. Terpenes may have helped combine the effects of THC and CBD, CBD and THC may have enhanced each other’s effects, or there may be a combination of the two (and possibly other explanations yet to be discovered).

Another study from 2010 showed slightly more convincing results. The study compared treatment protocols for persistent pain in cancer patients. Patients were treated with pure THC concentrate, pure CBD concentrate, a combination of the two or a placebo. The study found that CBD effectively relieved patients’ pain, while THC concentrate did not produce the same results. This finding points to the ability of CBD to enhance the healing effects of THC.

The same study revealed that the combination of THC and CBD is a suitable substitute for opioid painkillers, meaning that the use of THC and CBD isolates alone is sufficient to replace opioids in patient care and treatment regimens. This study provides evidence for a direct synergistic relationship between THC and CBD when it comes to the treatment of chronic pain.

4 Tips for Chronic Pain

There are many natural alternatives to help you manage chronic pain – regular exercise, a proper diet and even adding cannabis to your daily routine. We take a look at five natural tips to help you manage chronic pain.

Regular physiotherapy

There are many ways to manage and treat chronic pain, and one of them is to attend regular physiotherapy sessions. First, you need to find the best physiotherapist who has the right understanding of the different techniques needed. He or she should have in-depth knowledge of how to adapt the therapy to make it suitable for your condition.

Through therapy you should be able to discover the limits of your pain tolerance. The therapist should be able to use this knowledge to recommend flexibility exercises as well as stretching exercises that are suitable for your needs. Some even include aerobic exercises as well as therapies that help strengthen the core. Regular physical therapy will not only reduce your chronic pain, but you may also find a deeper state of relaxation.

Create a regimen with hemp and CBD

Hemp has been proven over the years to be one of the best natural herbs for aiding healing abilities. In addition to helping relieve symptoms of arthritis, skin inflammation and diabetes, cannabis can also minimize or treat chronic pain.

The use of cannabidiol is widespread and, like many herbal remedies, has no significant side effects. Cannabis also works with the endocannabinoid system to ensure that you get enough sleep, which in turn helps the whole body to relax.

CBD oils and other CBD products can help treat chronic pain associated with various conditions, including arthritis and multiple sclerosis. Some people even want to replace their medications with CBD!!!

There are many opportunities to incorporate hemp into your life. Some people prefer to smoke the plant through vaporizers, while others prefer pills or CBD oils.

Adjust your diet

Changing your diet is among the many natural chronic pain treatment tips you should always consider. The right foods and drinks can improve your mood and digestion, thus improving your overall well-being. One of the things that most people do when it comes to their nutritional needs is that they tend to ignore the signs of their food sensitivities.

Consider Kratom

This Southeast Asian herb is one of the best healing elements that can help treat various medical conditions such as diabetes, high blood pressure, diarrhea and post-traumatic stress disorder, among others. Unlike other opiates, Kratom does not make you feel tired and fuzzy. Kratom gives you a feeling of euphoria as well as providing a state of alertness and relaxation. Another reason why Kratom supplementation is so beneficial is that it eliminates numerous side effects that painkillers usually have. The use of kratom will also energize you and improve your sexual performance thanks to the corynantheidin compound it contains. You should also expect complete relaxation of your body, mind and spirit.

Daily meditation

Consider adding a daily meditation practice. It is one of the best ways to clear your mind and relieve chronic pain, and it costs almost nothing. It unlocks stagnant energy, ensuring a constant supply of fresh oxygen to all parts of the body. When the body and mind are relaxed, your mind will begin to focus on the deep-seated chronic pain.

It can be helpful to find a spiritual teacher who can help you easily achieve various meditative states. We also recommend that you consider adding cannabis to your meditation practice.

While these five natural tips will not cure your chronic pain, they can certainly help alleviate it. Each of these natural tips is great to add to your daily routine. We recommend starting with small steps, one step at a time, and getting additional guidance from qualified personnel. These five natural tips will help relieve chronic pain and help you find your way to freedom.

How to Use CBD for Pain

When creating a CBD regimen for pain (such as chronic pain or neuropathic pain), it is important to understand that CBD has not been proven to treat pain. However, anecdotal reports of success encourage many people to try the plant-based alternative by incorporating regular doses. It may be best to use it first as a preventative measure – it can also be used to manage acute flare-ups, but preventative care is most important! Think of it like any other nutritional supplement, you want to create a base concentration in your body.

There are a variety of different products made with CBD for pain, but we recommend taking a full-strength CBD oil in the form of a tincture or gel capsule daily.

The ingredients in both products are the same; the only difference between them is the form factor and dosage – sublingual tinctures versus tablets. The best CBD oil and gel capsules will combine the power of CBD for pain with high-quality MCT oil, a key ingredient your body needs to break down and absorb cannabidiol.

Many people still need a safe way to manage acute flare-ups in addition to using the products described above for daily pain management. Depending on your preference, there are several suitable options for dealing with sudden pain attacks.

Whether caused by a recent injury, cold weather or a general flare-up – we recommend CBD isolate vaporization to combat these acute pain attacks. The advantage of vaporizing or applying CBD isolate is that relief can be felt almost immediately. CBD isolate is 99% pure CBD and provides a wave of relief that can be felt throughout the body.

Some topical CBD medicines can also provide quick relief from pain attacks. Topicals such as CBD ointments and creams penetrate the skin and help manage pain in the bones, muscles, joints, tendons and skin surface.

Often the best way to manage pain caused by moderate to severe pain, recurrent pain or a number of chronic conditions is to combine different CBD products for preventive and therapeutic coverage all day.

What is the right CBD dose for pain?

The right dose for you depends on a number of factors, including the type and severity of the condition you are hoping to treat, as well as biological factors such as weight and tolerance to cannabinoid-based products.

For pain, we recommend starting with 5-10 mg of CBD per day. If you do not feel relief at this dose, we recommend increasing by 5-10 mg until the desired effect is achieved. An easy way to do this is with a CBD oil tincture, which makes it easy to measure precisely measured doses as needed each time.

Other products such as CBD pills and CBD softgels come in pre-measured doses, so starting with the lowest dose (such as 10 mg CBD per capsule) is a great way to figure out how much CBD you need to reach the desired level of relief.

You can then increase your dose as needed, but keep in mind that these ingestible medicines provide lasting relief for several hours – many people find that they provide relief for the whole day! The only thing to keep in mind with ingestible CBD products is the delayed onset – it can take up to 90 minutes for the full effects of tinctures or capsules to be felt.

The dosage of topical CBD products is slightly different and you should use as much product as needed to cover the affected area. Topical products are usually fast acting and relief can be felt within 15 minutes and can last for several hours. Reapply as needed.

Dosing for CBD vaporizers is also slightly different, as it can be difficult to measure doses accurately in some vaporizer devices. Starting with a low dose of cannabidiol vaporizer or CBD supplement can help you experience fast-acting effects smoothly. Because the therapeutic effects of CBD vapor for pain occur so quickly, you can easily “adjust” dosages as needed until you get the desired effect. Increase your dosage one “pull” at a time and wait about 10-15 minutes in between to monitor the effects.

Best CBD products for pain relief

Not sure where to find CBD products for pain relief? We have you covered. We realize that there is a dizzying number of options making it difficult to choose. So we’ve done the hard work for you and taken the guesswork out of which CBD products are the best!

Which are the best CBD products for pain relief?

All CBD products fall into three main categories. Full spectrum (sometimes called “hemp extract”), broad spectrum and isolated. You can see these labels on almost every CBD product. We will take a closer look at all three and see why achieving full-spectrum CBD is the undisputed winner for pain relief.

The difference between the three types has to do with the extraction method used in each. Isolate is CBD isolated from all other compounds in the cannabis plant. Broad spectrum retains the compounds in the cannabis plant but removes 100% of the THC (the psychoactive component of cannabis). Full spectrum uses all the compounds found in the cannabis plant, including traces of THC. But this is not enough to make you feel “high”.

There is a synergy between THC, CBD and other natural compounds in hemp called the “envelope effect”. To quickly summarize the research, you should always take CBD with all natural compounds intact. Isolating them from each other will not create the best possible effect, which means that you will not get the full pain relief you can get.

The correct dose depends on various factors. For example, your previous experience with CBD, the severity of your pain and your body weight. Research on CBD as a pain reliever is still in the very early stages, which means that there are no established guidelines for the exact dosage. However, some studies suggest that a higher potency is required for lasting pain relief. With this in mind, we have put together the 7 best CBD products for pain relief that typically contain higher doses of CBD. As with any new supplement or medication, you should use a low dose initially and gradually increase it until the desired effect is achieved.

BEST CBD OIL FOR CHRONIC PAIN Ambary Gardens Daily Full Spectrum Extra Strength 5000 CBD Oil

Ambary Gardens is one of our trusted brands and currently offers one of the most powerful full spectrum CBD extracts on the market. Each dropper contains 84 mg of CBD per dose. If you are trying CBD oil for the first time, you may want to start with an amount closer to 25-50 mg per dose with their 500 mg full spectrum tincture. It is worth noting that you can always control the amount with dropper measurements. There is even a handy guide on the product page on how to increase the dose directly according to your needs.

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BEST CBD PAIN RELIEF FOR JOINT PAIN

Hemp Bombs CBD Pain Freeze

Hemp Bombs CBD Pain Freeze provides instant relief by applying the cream directly to the source of the pain. Thanks to the added menthol, you will find a refreshing, cooling effect. You can also apply this scrub up to four times a day to soothe aching joints and limbs.

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Best CBD Salve for Irritated Skin

Joy Organics CBD Salve

Joy Organics has specially developed CBD Salve for dry and irritated skin. This salve gently heals and moisturizes chapped or rough skin. The all-natural CBD oils combined with aloe, olive oil and glycerin should be more than enough to nourish and soothe sensitive skin areas, while also helping to relieve any pain.

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Best Solution for Inflammation

Earth Medicine Recover Muscle Joint Gel

Earth Medicine is another crowd favorite and the most trusted brand in the product line. If you need a product that covers multiple uses, this 60mg full spectrum extract is perfect. Earth Medicine has patented MicroCBDTM + Robus Broad Spectrum CBD Oil combined with essential oils for an accelerated absorption rate. You have two potency options – 200 mg or 400 mg dose. As a pain reliever, it is made for post-workout aches and pains, but it can also help with many other ailments. As Earth Medicine says, you’ll be doing rotational movements in no time.

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BEST CBD OIL FOR PAIN

CBDDistillery’s Full Spectrum CBD Oil Tincture

In addition to having a wide range of products, CBDistillery consistently offers the best value for money. They have a large number of affordable CBD products. This full-spectrum tincture is the most affordable product on this list and is a great choice for someone who is just starting to understand how CBD can help them manage pain. Don’t worry about low potency, because you can always double or triple it until you find your sweet spot.

5% Discount Code: Our goal at The CBD Encyclopedia is to help our readers find CBD products that support their health and well-being goals, primarily through consumer education. This includes not only the science behind CBD products, but also their impact on the environment. As our society becomes more conscious of our relationship with (and dependence on) our planet and the ecosystems it supports, the sustainability of ingredients is becoming increasingly important to many people (including us).

While there is value in making better purchasing decisions, we recognize that “better” never means “perfect”. Our goal is not to shame anyone for making the decisions they think are best for them (in fact, those are exactly the decisions we want to support), but to encourage conscious consumption whenever possible. What that looks like for you is entirely up to you, and we always want to give you the opportunity to determine that for yourself.

Whenever possible, we specifically prefer to choose plant-based ingredients for topical CBD products rather than petroleum-based products. There are two main reasons for this: First, petroleum is a finite resource and has a huge environmental impact at every stage, from extraction to refining, transportation and consumption. Secondly, a link has been established between long-term use of some topical petroleum products and cancer later in life.

We too prefer plant products to those derived from animals, but we realize that not everyone agrees. Some animal products, such as beeswax, lanolin and gelatin, are important components of many of our readers’ healthy lifestyles, and this is true. While it is true that there are vegan alternatives to these ingredients, they are not suitable options for everyone. Also, there are some nuances in the “vegan” labeling.

The “vegan” description on the product label indicates that the product contains no animal products. However, this does not necessarily mean a more sustainable product. Microplastics, knitwear, plastic leather, polyester and petroleum products are considered ‘vegan’ but are no more environmentally friendly than their animal counterparts. We do not want to say that the ‘vegan’ label is meaningless, but we suggest that it is not the only criterion by which the quality or sustainability of a product is measured.


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